Gene Expression Analysis Using Fuzzy ART
نویسندگان
چکیده
The recent advances of genome-scale sequencing and array technologies have made it possible to monitor simultaneously the expression pattern of thousands or tens of thousands of genes. One of the following steps is to discover or extract the information for the genetic networks by analyzing such massive data sets. Therefore, various clustering methods, such as hierarchical clustering [3] or selforganizing maps [5], have been examined and used to elucidate the fundamental or/and characteristic expression pattern. We have applied a fuzzy adaptive resonance theory (Fuzzy ART) model, a type of unsupervised clustering method, to the experimental data [6]. In the present paper, we verified the clustering results using Fuzzy ART by comparing with those of hierarchical clustering, k-mean clustering and self-organizing maps (SOMs).
منابع مشابه
Modification of the Fast Global K-means Using a Fuzzy Relation with Application in Microarray Data Analysis
Recognizing genes with distinctive expression levels can help in prevention, diagnosis and treatment of the diseases at the genomic level. In this paper, fast Global k-means (fast GKM) is developed for clustering the gene expression datasets. Fast GKM is a significant improvement of the k-means clustering method. It is an incremental clustering method which starts with one cluster. Iteratively ...
متن کاملGene Expression Analysis Using Fuzzy K-Means Clustering
The recent advances of array technologies have made it possible to monitor huge amount of genes expression data. Clustering, for example, hierarchical clustering, self-organizing maps (SOM), kmeans clustering, has become important analysis for such gene expression data. We have applied the Fuzzy adaptive resonance theory (Fuzzy ART) [5] to the gene clustering of DNA microarray data and the clus...
متن کاملAnalysis of expression profile using fuzzy adaptive resonance theory
MOTIVATION It is well understood that the successful clustering of expression profiles give beneficial ideas to understand the functions of uncharacterized genes. In order to realize such a successful clustering, we investigate a clustering method based on adaptive resonance theory (ART) in this report. RESULTS We apply Fuzzy ART as a clustering method for analyzing the time series expression...
متن کاملInference of common genetic network using fuzzy adaptive resonance theory associated matrix method.
Inferring genetic networks from gene expression data is the most challenging work in the post-genomic era. However, most studies tend to show their genetic network inference ability by using artificial data. Here, we developed the fuzzy adaptive resonance theory associated matrix (F-ART matrix) method to infer genetic networks and applied it to experimental time series data, which are gene expr...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2001